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Tuberculosis vaccine trialled for COVID-19

Elizabeth Gracie
The Murdoch Children’s Research Institute (MCRI) is running a clinical trial, using the BCG vaccine, which inoculates against tuberculosis, as an immunity booster against the novel coronavirus.

Essential health care workers in Australia, Spain, and the Netherlands will be the first to receive it, to help protect them against exposure.

After receiving a $10m grant from the Bill and Melinda Gates Foundation, the BRACE (BCG vaccination to Reduce the impact of COVID-19 in Australian healthcare workers following Coronavirus Exposure) trial hopes to reach its target of 4000 healthcare workers by the end of the month. Some 2500 have already enrolled in Australia.

The BRACE trials hope to uncover whether a BCG vaccination can successfully protect a frontline health worker from novel coronavirus or even reduce the severity of the health impacts for those infected by boosting their frontline immunity. 

Professor Nigel Curtis, Head of MCRI’s Infectious Diseases Research Group believes that this research is crucial, noting, “It is imperative to help your researchers show whether the BCG vaccination improves ‘innate’ immunity to frontline healthcare workers to buy time to develop and importantly, validate, a specific anti-COVID-19 vaccine”.

The rapid expansion of the BRACE research has been funded by philanthropic support. After receiving initial funding from the Bill and Melinda Gates Foundation, the trial has now received $700,000 from Sarah and Lachlan Murdoch, $400,000 from the Royal Children’s Hospital Foundation (RCHF), $1.5m from the Minderoo Foundation and $200,000 from the South Australian government.

According to Curtis, this new funding has accelerated the start of the trials. 

“These sorts of trials normally take around eight to twelve months to start, but with the early support of philanthropy, we were able to start in record time, within three weeks”.

“Since beginning the BRACE trial we have been inundated with requests from other hospitals wanting to be involved, both in Australia and internationally. This funding will allow us to begin delivering on those requests” said Curtis. 

The Radboud University Medical Centre in the Netherlands and UMC Utrecht in Spain will commence the enrolment processes in the coming weeks. 

Professor Marc Bonten from UMC Utrecht said that “we are very pleased to join this international trial to see if BCG can help lessen COVID-19 symptoms in Dutch healthcare workers”.

Mihai Netea, a Professor at Radboud University Medical Centre, is also excited to take part in the study, and says, “At Radboud UMC we have spent more than 10 years investigating BCG’s off-target effects, including previous research with Professor Curtis. In a time of crisis such as this, we thank the Bill and Melinda Gates Foundation for their agile and generous contribution”.

And whilst Australia has proven itself a global leader in flattening the curve against novel coronavirus, MCRI Director Kathryn North says that “we are still in a race against time due to our position to help the rest of the world”. 

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