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Metcalf prize winners bag $50,000 for stem cell research

Jessica Guttridge

Two researchers are using stem cells to address problems and gaps of understanding in heart and breast tissue

 The cells responsible for milk expulsion during lactation. Credit: Dr Felicity Davis, Mater Research Institute, UQ

The National Stem Cell Foundation of Australia (NSCFA) has awarded $50,000 to two researchers, helping further fund studies of mammary glands and bioengineered human hearts, as part of the annual Metcalf competition. 

Each year, the National Stem Cell Foundation of Australia awards and celebrates two exceptional mid-career stem cell researchers with the Metcalf Prizes for Stem Cell Research. 

The prizes support the National Stem Cell Foundation of Australia’s mission to promote the study and use of stem cells in the prevention or control of disease in human beings and to enhance stem cell public education.

Associate Professor James Hudson of the QIMR Berghofer Medical Research Institute studies the human heart, and how its cells must last a lifetime without renewal. To better understand this, he has made more than 20,000 beating ‘mini-hearts’, called organoids.

“Heart muscle cells essentially have one job to do throughout our lives. They don’t like change and are difficult to regenerate,” he says.

As well as using them to study diseases and test new pharmaceuticals, Hudson deploys the organoids to study how heart muscle cells obtain and use energy, and how this influences their ability to regenerate. His goal is to make new tissue to repair damaged hearts.

“In five years, I hope we will be closer to or even starting clinical trials for stem cell-derived patches for cardiovascular repair and for drug candidates we helped identify, with many more treatments in the pipeline behind them,” he says.

Dr Felicity Davis of the University of Queensland’s Mater Research Institute is investigating the secret life of mammaries: how they develop, how they change during pregnancy and breastfeeding, and how things can go wrong.

Discovering how this happens at a molecular, cellular and tissue level will provide new insights when problems in the breast arise – ranging from breastfeeding difficulties to breast cancer.

“Breast stem cells live in a world of change – from a basic mammary structure in the embryo, to rapid growth during puberty, and then drastically changing again with each pregnancy,” she says.

“We should be doing everything we can in order to understand how that happens physiologically, how the breast changes to allow that to happen and how it remodels after the process is complete.”

Both researchers are transforming our understanding of how other scientists might work with stem cells to understand, prevent and treat disease, and have been recognised by the Foundation for their early-career leadership in stem cell research. 

“We hope that supporting Felicity Davis’ work will help make a difference in this important area of women’s and children’s health, and that James Hudson’s work will help us tackle Australia’s biggest killer,” says Dr Graeme Blackman AO, the chairman of the Foundation.

“Both scientists are great examples of the depth and breadth of stem cell research undertaken in Australia – all of it bringing us closer to important clinical outcomes.”

The awards are named for the late Professor Donald Metcalf AC, who, over a 50-year career, helped transform cancer treatment and transplantation medicine, paving the way for potential stem cell therapy in the treatment of many other conditions.

The National Stem Cell Foundation of Australia is a philanthropic foundation drawing from diverse backgrounds in stem cell science, 
medicine, and finance to supports stem cell science and educate the community about the potential and dangers of stem cell therapies.

Professor Hugh Taylor AC will present the 2019 Metcalf Prizes for Stem Cell Research at a special event in Melbourne on Thursday 28 November 2019.

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