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Malaria vaccine development boosted by breakthrough

Elizabeth Gracie
A team of researchers from the Australian National University (ANU) have identified the shortcomings in vaccine development for malaria, in a breakthrough they hope will lead to a long-term solution.  

In 2018, there were 228 million cases of malaria, leading to half a million deaths, according to the World Health Organisation.

Lead author of the study originally published in Cell Host & Microbe, PhD scholar Hayley McNamara said that long-lasting immunity against malaria could not be achieved with current vaccination strategies. 

According to McNamara and her team, complex diseases such as HIV and Malaria require large quantities of antibodies to be present before immunity can develop.

“We have found that antibody-based protection against malaria is difficult to achieve as the body cannot generate enough protective antibodies through the vaccine,” said McNamara.

“Malaria vaccines are failing because they only provide immunity against one surface protein of the parasite,” said McNamara.

“However our research shows that vaccines should instead target an array of the parasites surface proteins in order to provide protection from malaria”

Currently, nearly half of the world’s population live in high-risk transmission areas for malaria, many of which exist in third world countries with limited access to healthcare. 

The World Health Organisation says that there is currently no commercially available vaccine for malaria as the complexity of the malaria parasite makes the development of a malaria vaccine a very difficult task.

According to ANU, the research has found that the negative feedback system may be overcome by tailoring malaria vaccines to target a diversity of the parasite’s surface protein. 

This negative feedback mechanism prevents malaria-specific antibodies from reaching the necessary protective levels. 

“Using a novel model, we found that the negative feedback mechanism may be overcome by strategically designing vaccines to direct antibody responses against different targets on the malaria parasite,” said McNamara. 

The findings have the potential to aid in the vaccine design for other complex diseases such as HIV that also require high levels of antibodies to be present for longstanding protection. 

Study lead, Association Professor Ian Cockburn says that the discovery could be crucial for hosts of other diseases that currently have no suitable vaccine candidate. 

“Our work has highlighted an important mechanism that future vaccine design should be taken into consideration,” said Cockburn. 
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